Thousands of people around the world are trying to figure out how to kill antibiotic-resistant bacteria. Colleagues at Copenhagen University have now discovered a hitherto unknown weakness in dental practice.This Achilles heel is a key step in the bacterial energy metabolism: a proton pump, which begins to leak when the bacterium is considered "dangerously acidic" as a result of the pH balance. Experts hope that the discovery will lead to the development of drugs that take advantage of this natural weak point. This imbalance is the source of the microbe Adenosine trifoszfбt (ATP), which acts on most biological processes in bacteria.
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In their research published in the Journal of the American Chemical Society, experts attempted to find out whether manipulating this pH imbalance could eliminate the pathogens. After conducting a series of experiments, it was found that the pH balance generated was manipulation of a proton pump can be influenced. They realized that when the inside of the bacteria becomes acidic, the pumps start to leak. In other words, when the imbalance between the inside and outside of the cells increases excessively, the pumps begin to leak.
Sune Jorgensen researcher said that a miniature electrode was made to control the pump, that is, turn it on and off, and the microscope slide was coated with 30 nanometers of gold. This is too small to be seen, while still conducting the current, allowing the pump to be switched on and off with the aid of an electric current.
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